Valentina Stevenson, DVM, PhD, DACVP

Valentina is an Anatomic Pathologist specializing in oncologic diseases, with a particular interest in the mechanisms of immunotolerance. Her previous work focused on exploring the immune profiles of two distinct canine neoplasia, melanoma and soft tissue sarcoma. While melanoma is highly immunogenic, it can still evade immune surveillance, whereas soft tissue sarcoma is poorly immunogenic. She conducted an evaluation of immune inhibitory checkpoint molecules and Tumor Infiltrating Lymphocytes (TILs), and found that despite their distinct immune profiles, the expression of these molecules was higher in malignant tumors. She also investigated the effects of Histotripsy Tumor Ablation Therapy on the expression of these molecules and observed a focal decrease associated with the treatment areas. Her findings indicate that immunotherapies targeting checkpoint molecules have great potential for efficacy in canine neoplasms, either alone or in combination with tumor ablation therapies that increase immune cell infiltration in poorly immunogenic neoplasia. At UF, Valentina plans to continue researching mechanisms of immunotolerance in neoplastic diseases, focusing on how checkpoint molecules can limit the host immune system, leading to tumor immune escape and metastasis. She is excited to explore how our understanding of the immune system can be used to develop and apply new therapeutic agents in comparative and translational medicine. Outside of work, she enjoys photography and outdoor activities with her family and dogs, including trail running.